Friday, July 24, 2015

Product Focus: Inhibitors – AZD3147 mTORC1/2 & AZD8186 PI3Kβ /δ, limited availability

AZD3147 mTORC1/2 and AZD8186 PI3Kβ /δ inhibitors are now available only from Reagency until the 21st August 2015.


AZD3147 mTORC1/2 RGNCY-0025

 



AZD3147 is novel urea containing morpholinopyrimidine compound and is an extremely potent and selective dual inhibitor of mTORC1 (rapamycin sensitive complex) and mTORC2 (rapamycin insensitive complex).  It has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.  mTOR enzyme IC50  = 0.0015μM, mTOR cells IC50 = 0.006μM, PI3Kα,β,δ,γ enzyme IC50 = 0.92, 5.5, 9.4 and 6.3 μM respectively. RGNCY-0025 10mg.



Systematic Name: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

SMILES: CN(C)C(C1=CC2=C(OC(N3CCOCC3)=CC2=O)C([C@@H](C)NC4=CC(F)=CC(F)=C4)=C1)=O

Chemical Formula: C24H25F2N3O4

Molecular Weight: 457.48

PMID: 25514658


AZD8186 PI3Kβ /δ RGNCY-0028

 



AZD8186 is a clinical candidate optimized from a series of  8-(1-anilino)ethyl)-2-morpholino-4-oxo-4H -chromene-6-carboxamides as PI3Kβ /δ  inhibitors.  AZD8186 has high metabolic stability and suitable physical properties for oral administration. It showed profound pharmacodynamic modulation of p-Akt in PTEN deficient PC3 prostate tumor bearing mice after oral administration. It also showed complete inhibition of tumor growth in the mouse PTEN-deficient PC3 prostate tumor xenograft model. AZD8186 was selected as a clinical candidate for treatment of PTEN deficient cancers and has recently entered phase I clinical trials. PI3Kβ IC50 = 0.003μM, PI3Kδ IC50 = 0.017μM, PI3Kα IC50 = 0.752μM. RGNCY-0028 10mg


Systematic Name: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

SMILES: CN(C)C(C1=CC2=C(OC(N3CCOCC3)=CC2=O)C([C@@H](C)NC4=CC(F)=CC(F)=C4)=C1)=O

Chemical Formula: C24H25F2N3O4

Molecular Weight: 457.48

PMID: 25514658



Reagency allows you to share the cost of custom synthesis through group purchasing, anonymously and securely. You can now purchase the latest literature compounds at much more economical prices than synthesising the compounds yourself. Get the amount you want without blowing the budget.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.

Tuesday, July 14, 2015

Supplier Focus: Fitzgerald Industries International – Tumour Markers & Antibody Pairs

Fitzgerald Industries International is a premier provider of over 50,000 products including polyclonal and monoclonal antibodies, purified proteins, research ELISA kits, and specialty products in numerous research areas.
They offer over 2,000 products spanning a vast range of cancer-related targets including, tumour markers, cell death and survival pathways, growth factors, oncogenes, signaling molecules, and cell division pathways. For more than 20 years, commercial diagnostic companies and research institutions across the globe have known they can depend on Fitzgerald Industries to supply high quality products to ensure the success of their research.

 

Produced for Cutting Edge Cancer Research

Fitzgerald Industries understand that cancer research is one of the most important areas of cutting edge research, with millions of scientists worldwide dedicating their careers to finding cures and treatments to this devastating disease.
Fitzgerald Industries prides itself on the wide range of products which we progressively introduce in the area of cancer and tumour studies. They aim to provide high quality tools to study existing and emerging targets to aid researchers to continue to unfold the intricate
cellular models, and to the discover causes and treatments.

 

Vast Array of Cancer Targets

Fitzgerald Industries have an extensive list of antibodies and proteins relating to cancers of the breast, prostate, lung, ovary, testis, stomach, bladder, kidney, andbrain, for example; HE4, BRCA, MUC1, CA 15-3, CA 19-9, CA 27-29, CA 125, ERBB2, CEACAM, Neu, c-myc, Survivin, p53, IGF, CEA, AFP, PSA, PAP, and hundreds more.

 

Validated Matched Pair Antibodies

Not only do we offer a vast array of targets, we also have validated matched pair antibodies which we can recommend for capture and detection in sandwich based immunoassays, and related proteins for use as controls.
These off-the-shelf reagents will save you time, stress, and money in assay development, removing the need for optimisation of your own reagents, while giving sensitive and robust results.



Where can I find more information about Fitzgerald Industries International?

Visit the manufacturer page at www.stratech.co.uk/fitzgerald, email info@stratech.co.uk or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.

Friday, July 10, 2015

Product Focus: FDA-approved Drug Library

Description & Advantages

  • A unique collection of 1018 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS)
  • Locate new targets for old drugs
  • Bioactivity and safety confirmed by clinical trials
  • All compounds have been approved by FDA
  • Related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc
  • Structurally diverse, medicinally active, and cell permeable
  • Rich documentation with structure, IC50, and customer reviews
  • NMR and HPLC validated to ensure high purity

 

Product Details

Formulation:     A collection of 1018 FDA approved drugs supplied as pre-dissolved DMSO solutions
Container:     96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

 

You Can Customize Your Library by Cherry Picking



Not only can you personalize your library with chemicals from within Selleck’s inventory, but we can also purchase chemicals from other companies and integrate them into your custom library.

 

FDA-approved Drug Library Contents

http://file.selleckchem.com/img_ad/FDA-approved-Drug-Library.jpg
FDA-approved Drug Library Composition (click on image)


Where can I find more information about Selleck Chemicals?

Visit the manufacturer page at www.stratech.co.uk/selleck_chemicals, email info@stratech.co.uk or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.